botulinum toxin for treatment of blepharospasm and hemifacial spasm
نویسندگان
چکیده
botulinum toxin produced by clostridium butolinum in one of the most fatal toxins known. botulism is the name given to condition produced by this toxin. in recent years the diluted form of this toxin has been produced in injection form and used for treatment of hemifacial spasm and blepharospasm. this toxin blocks neuromuscular junction and inhibits acetylcholine release. in this article we reported 36 patients suffering from hemifacial & blepharospasm treated by injections of botulinum a toxin. 85 to 90 percent of patients responded well. the common complications of this drug were ptosis, hemifacial paresis, burning of the mouth and discoloration of the injection site. generally speaking the patients preferred this toxin to taking oral medications which were less effective.
منابع مشابه
Botulinum a toxin treatment of hemifacial spasm and blepharospasm.
We studied the effects of botulinum A toxin in 101 patients with hemifacial spasm and 11 patients with blepharospasm in an open trial and double blind manner. All patients in the open trial and 6 patients in the double blind trial improved after the first injection of botulinum toxin. There was no improvement with placebo. The peak effect ranged from one to 6 days after injection and mean peak ...
متن کاملBlepharospasm and hemifacial spasm: long-term treatment with botulinum toxin.
INTRODUCTION Our purpose is to describe the demographic, clinical and therapeutic characteristics of patients with blepharospasm (BS) and hemifacial spasm (HFS) in treatment with botulinum toxin type A (BtA). PATIENTS AND METHODS Retrospective analysis of patients diagnosed with BS or HFS and treated with BtA in the Neurology Department at Complejo Asistencial de Segovia between March 1991 an...
متن کاملBotulinum toxin A in blepharospasm and hemifacial spasm.
We report the first Indian experience of botulinum toxin A in the treatment of blepharospasm and hemifacial spasm. Sixteen patients, 7 with essential blepharospasm, 5 with Meige syndrome and 4 with hemifacial spasm received botulinum toxin A injection. One patient received 3 courses of injections, 2 received 2 courses and the rest received only one course. The effect was observed after a latent...
متن کاملBotulinum toxin type B in blepharospasm and hemifacial spasm.
Botulinum neurotoxins (BTXs) inhibit the presynaptic release of acetylcoline causing a chemical denervation that results in sustained muscle weakness and have been used in the past 20 years to induce selective blocking of hyperactive striatal (and smooth) muscles. All the different seven serotypes of BTXs have in common the mechanism of action (block of the neuroexocytosis machinery inside the ...
متن کاملBotulinum toxin type B in blepharospasm and hemifacial spasm
Botulinum neurotoxins (BTXs) inhibit the presynaptic release of acetylcoline causing a chemical denervation that results in sustained muscle weakness and have been used in the past 20 years to induce selective blocking of hyperactive striatal (and smooth) muscles. All the different seven serotypes of BTXs have in common the mechanism of action (block of the neuroexocytosis machinery inside the ...
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عنوان ژورنال:
مجله دانشکده پزشکی دانشگاه علوم پزشکی تهرانجلد ۵۵، شماره ۱، صفحات ۳۴-۳۹
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